Author: Mr Oliver Eaton BSc (Hons), PG.Cert – Orthopaedic Specialist
Reviewed by: Mr William Sharples BSc (Hons) – Pain Management Expert
Last Updated: September 2025
In this article, you will find out everything you need to know about Arthritis flare-ups and the most effective ways to treat them, including an advanced treatment called Prolotherapy.
Arthritis Flare Ups: Causes, Relief, and Long-Term Solutions
Introduction
Arthritis flare ups can be unpredictable, painful, and disruptive to daily life. Whether you have osteoarthritis, rheumatoid arthritis, or another form, understanding what causes flare ups and how to manage them is essential for long-term joint health and quality of life. This guide covers the latest evidence, expert advice, and advanced treatments—including prolotherapy—to help you take control of arthritis flare ups.
What is an Arthritis Flare Up?
An arthritis flare up is a period of increased joint pain, swelling, stiffness, and fatigue that can last from a few hours to several weeks. Flare ups can occur suddenly and may affect one or multiple joints. They are common in both inflammatory arthritis (like rheumatoid arthritis) and degenerative arthritis (like osteoarthritis) [1].
Symptoms of Arthritis Flare Ups
- Intense joint pain and tenderness
- Increased swelling and warmth
- Stiffness, especially in the morning or after rest
- Fatigue and low energy
- Reduced range of motion
- Difficulty performing daily activities
- Sometimes fever or flu-like symptoms (in inflammatory arthritis)
The severity and duration of symptoms can vary from person to person.
Common Triggers
Identifying and avoiding triggers can help reduce the frequency and severity of arthritis flare ups. Common triggers include:
- Overuse or injury to the joint
- Stress and lack of sleep
- Weather changes (cold, damp, or sudden shifts)
- Infections or illness
- Poor diet or dehydration
- Missing medication doses
- Hormonal changes
Keeping a symptom diary can help you and your healthcare provider identify your personal triggers [2].
Case Studies
Case Study 1: Osteoarthritis Flare Up
A 68-year-old woman with knee osteoarthritis experienced a sudden flare after a long walk. She reported severe pain, swelling, and difficulty sleeping. After rest, ice, and a short course of anti-inflammatory medication, her symptoms improved. She later started prolotherapy at ProHealth Clinic and reported fewer and less severe flare ups over the following year.
Case Study 2: Rheumatoid Arthritis Flare Up
A 42-year-old man with rheumatoid arthritis developed a flare after a viral infection. He experienced joint pain, fatigue, and low-grade fever. His rheumatologist adjusted his medication and recommended gentle exercise and stress management. He also received prolotherapy, which helped reduce the frequency of future flares.
Treatments for Arthritis Flare Ups
Managing arthritis flare ups involves a combination of self-care, medical treatment, and long-term strategies:
- Rest and Joint Protection: Avoid activities that worsen pain. Use braces or supports if needed.
- Cold or Heat Therapy: Ice packs reduce swelling; heat pads ease stiffness.
- Medications: NSAIDs, acetaminophen, or corticosteroids may be prescribed for short-term relief [3].
- Physical Therapy: Gentle stretching and strengthening exercises can help maintain mobility.
- Stress Management: Mindfulness, relaxation techniques, and adequate sleep support recovery.
- Diet and Hydration: Anti-inflammatory diets and staying hydrated may help reduce flare frequency.
- Reviewing Medications: Work with your doctor to ensure your treatment plan is up to date.
For those seeking long-term relief and fewer flare ups, regenerative treatments like prolotherapy are increasingly recommended.
Prolotherapy
In recent years, Prolotherapy has built its reputation within the medical community for its clinically proven ability to treat arthritis flare ups.
Published research has proven its pain-relieving, anti-inflammatory and regenerative benefits.
Prolotherapy involves injecting a natural regenerative solution with tiny needles. This has been shown to stimulate the production of collagen cells, the small cells needed to help with arthritis flare ups.
As prolotherapy is helping to treat the root cause of arthritis flare ups, it is deemed to be a permanent fix, preventing the symptoms from returning.
A 2016 systematic review in Clinical Rehabilitation found that prolotherapy significantly reduced pain and improved function in patients with osteoarthritis and chronic joint pain, leading to fewer and less severe flare ups [4].
At ProHealth Clinic, our experienced practitioners have helped thousands of patients achieve lasting relief from arthritis flare ups through prolotherapy.

Frequently Asked Questions
What is the difference between an arthritis flare up and everyday pain?
Everyday arthritis pain is usually stable and manageable, while a flare up is a sudden, intense increase in pain, swelling, and stiffness that can disrupt daily activities.
How long do arthritis flare ups last?
Flare ups can last from a few hours to several weeks, depending on the type of arthritis, severity, and treatment.
Can I prevent arthritis flare ups?
While not all flare ups can be prevented, identifying and avoiding personal triggers, following your treatment plan, and maintaining a healthy lifestyle can reduce their frequency and severity.
When should I see a doctor for an arthritis flare up?
Seek medical advice if your flare up is severe, lasts longer than usual, or is accompanied by fever, redness, or other unusual symptoms.
Is prolotherapy safe for arthritis flare ups?
Yes, prolotherapy is considered safe when performed by experienced practitioners. It is minimally invasive and has a low risk of side effects.
How can I book a consultation at ProHealth Clinic?
You can contact us by phone or email to arrange a free 15-minute discovery call. See contact details below.
Contact ProHealth Clinic Today for Your FREE 15-Minute Discovery Call
Don’t let arthritis flare ups control your life any longer. Join the thousands of patients who have found lasting relief through prolotherapy at ProHealth Clinic.
Get in Touch
Phone: Call Us Now
Email: info@prohealthclinic.co.uk
Our Clinic Locations
London: 104 Harley Street, Marylebone, W1G 7JD
Manchester: The Hadley Clinic, 64 Bridge Street, M3 3BN
Bedford: The Village Medical Centre, Kingswood Way, MK40 4GH
All clinics offer the same award-winning prolotherapy treatment with convenient appointment times, including evenings and weekends.
Author Bio
References
- Smolen, J. S., et al. (2016). Rheumatoid arthritis. Lancet, 388(10055), 2023-2038. https://doi.org/10.1016/S0140-6736(16)30173-8
- National Rheumatoid Arthritis Society. (2023). Managing a Flare. https://www.nras.org.uk/resource/managing-a-flare/
- National Institute for Health and Care Excellence (NICE). (2022). Osteoarthritis: care and management. https://www.nice.org.uk/guidance/cg177
- Rabago, D., et al. (2016). Prolotherapy for osteoarthritis and tendinopathy: a systematic review. Clinical Rehabilitation, 30(10), 944-959. https://doi.org/10.1177/0269215515621111
Disclaimer: This article is for informational purposes only and does not substitute for professional medical advice. Always consult your healthcare provider before making treatment decisions.

