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Rheumatoid Arthritis Flare Up Treatment: Relief & Evidence

Author: Mr Oliver Eaton BSc (Hons), PG.Cert – Orthopaedic Specialist
Reviewed by: Mr William Sharples BSc (Hons) – Pain Management Expert
Last Updated: September 2025

In this article, you will find out everything you need to know about rheumatoid arthritis flare-ups and the most effective treatments available, including an advanced treatment called prolotherapy

What Is a Rheumatoid Arthritis Flare Up?

Rheumatoid Arthritis Flare Up in the wrist

A rheumatoid arthritis flare up is a period of increased joint pain, swelling, stiffness, and fatigue—these are common rheumatoid arthritis symptoms. Flares can last from a few days to several weeks and may affect one or multiple joints, with pain and swelling as key indicators. Joint stiffness and a painful joint are also typical during a flare. They are a hallmark of RA (rheumatoid arthritis (RA)) and are often referred to as RA symptoms and can significantly impact quality of life [1].

What Causes RA Flare Ups?

  • Infection: Viral or bacterial infections can trigger immune system activity and joint inflammation.
  • Stress: Physical or emotional stress can worsen symptoms.
  • Medication changes: Missing doses or stopping medication can lead to flares.
  • Weather changes: Cold, damp, or sudden weather shifts may increase pain and stiffness.
  • Overexertion: Excessive physical activity or joint strain can trigger a flare.
  • Dietary triggers: Some people report flares after eating certain foods (e.g., processed foods, sugar, alcohol).
  • Hormonal changes: Menstruation, pregnancy, or menopause can influence flares.
  • Unknown factors: Sometimes, flares occur without a clear cause.

Genetic and environmental risk factors, such as family history and exposure to certain irritants, can increase the likelihood of developing rheumatoid arthritis.

Identifying your personal triggers can help you prevent or minimize future flares [2].

Rheumatoid arthritis is an autoimmune disease, meaning the immune system mistakenly attacks healthy joint tissue. In the early stages, immune activation and inflammation can begin before noticeable symptoms appear.

Symptoms of a Rheumatoid Arthritis Flare Up

  • Increased joint pain, swelling, and stiffness
  • Fatigue and low energy
  • Warmth or redness around affected joints
  • Difficulty moving or performing daily activities
  • Other joint symptoms, such as increased sensitivity or reduced range of motion, may also occur during a flare.
  • Low-grade fever (in some cases)
  • Sleep disturbances

How Are RA Flares Diagnosed?

Diagnosis is based on your symptoms, medical history, and a physical examination. Your doctor may order blood tests (e.g., ESR, CRP) to check for inflammation, or imaging (X-rays, ultrasound) to assess joint damage. It’s important to distinguish a flare from an infection or other medical issue [3].

Treatments for Rheumatoid Arthritis Flare Ups

Doctor using model to show Rheumatoid Arthritis in the knee

A comprehensive rheumatoid arthritis treatment plan may involve medications, lifestyle changes, and multidisciplinary support. Relieving pain and improving function are primary goals of any treatment plan. The best treatment for a flare up depends on its severity and your overall health. Options include:

    • Medications: NSAIDs, corticosteroids, and disease-modifying antirheumatic drugs (DMARDs) to reduce inflammation. These medications work by targeting the immune system attacks that cause joint inflammation. NSAIDs can affect blood flow in the kidneys and other body systems, so monitoring is necessary.
    • Early treatment and initial treatment with DMARDs and corticosteroids are crucial to prevent joint damage and improve long-term outcomes.
    • Other drugs, such as gold salts and biologics, are also used to treat RA, with clinical studies providing evidence supporting their effectiveness.
    • Rest and joint protection: Limit activity and use splints or braces if needed. Using assistive devices can help offload a damaged joint and reduce pain.
    • Cold or heat therapy: Ice packs reduce swelling; heat relieves stiffness. A hot shower in the morning can help relieve joint stiffness and pain.
    • Physical therapy: Gentle exercises to maintain mobility and strength. An occupational therapist can provide training and support devices to help protect joints and maintain daily function. Therapies should consider the impact of RA on multiple body systems, not just the joints.
    • Stress management: Mindfulness, relaxation, and support groups can help. Patient education on managing stress and recognizing flare triggers is essential for effective self-management.
    • Dietary adjustments: Anti-inflammatory diets may help some people. Monitoring for weight gain is important, especially if corticosteroids are used.
  • Alternative therapies: Acupuncture, massage, and meditation may provide additional relief for some patients. Complementary therapies, such as acupuncture and massage, may offer short-term relief.
  • Nutritional supplements like omega-3 fatty acids and curcumin may help reduce inflammation and support joint health.
  • A TENS machine may be used for pain relief by applying electrical stimulation to numb nerve endings.

Prolotherapy

In recent years, Prolotherapy has built its reputation within the medical community for its clinically proven ability to treat rheumatoid arthritis.

Published research has proven its pain-relieving, anti-inflammatory and regenerative benefits.

Prolotherapy involves injecting a natural regenerative solution with tiny needles. This has been shown to stimulate the production of collagen cells, the small cells needed to help with rheumatoid arthritis.

As prolotherapy is helping to treat the root cause of rheumatoid arthritis, it is deemed to be a permanent fix, preventing the symptoms from returning.

Click here to find out about our award winning arthritis clinic

Disclaimer: The information provided in this section is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Prolotherapy may not be suitable for everyone, and outcomes can vary. Always seek the guidance of a qualified healthcare professional regarding your specific medical condition or treatment options. Never disregard professional medical advice or delay seeking it because of information you have read here.

Analgesic Drugs and Pain Management During Flares

Managing rheumatoid arthritis pain during a flare often requires a combination of strategies, with analgesic drugs playing a key role. Over-the-counter pain relievers like acetaminophen or naproxen sodium can help reduce joint pain and inflammation, making it easier to get through daily activities. However, because rheumatoid arthritis often requires a specific drug regimen, it’s important to talk to your healthcare provider before adding or changing any medications. They can help you choose the safest and most effective options for your situation.

In addition to medication, non-drug approaches can also help relieve pain. Cold therapy, such as applying ice packs to swollen joints, can decrease inflammation and numb painful areas. Deep breathing exercises and other relaxation techniques can help manage stress, which may otherwise worsen rheumatoid arthritis pain. By combining these methods, you can find greater relief and support your overall well-being during flare ups.


Lifestyle Changes to Support Flare Recovery

Adopting healthy lifestyle habits can make a significant difference in how you recover from rheumatoid arthritis flares and may even help prevent future flare ups. Maintaining a healthy weight through a balanced diet and regular physical activity can reduce stress on your joints and minimize joint damage. Gentle exercises, such as tai chi or yoga, are especially beneficial—they help improve muscle strength, flexibility, and balance, while also easing pain and stiffness.

Incorporating deep breathing exercises and other relaxation techniques into your daily routine can help manage stress and support your body’s recovery process. Prioritizing restful sleep and listening to your body’s signals are also important steps in managing arthritis flares. By making these lifestyle changes, you can help ease pain, reduce the severity of symptoms, and support your long-term health.


Coping with Arthritis Flares: Emotional and Practical Strategies

Living with rheumatoid arthritis means learning to cope with both the physical and emotional challenges of flare ups. Staying positive and focusing on what you can control is key to managing symptoms and maintaining your quality of life. Emotional support from friends, family, or support groups can make a big difference, helping you feel less isolated and more empowered.

On a practical level, prioritizing self-care is essential. Take regular breaks, pace yourself, and use assistive devices when needed to make daily tasks easier and reduce strain on your joints. Occupational therapy can provide valuable guidance on adapting your home and work environments, as well as strategies for minimizing joint damage and managing arthritis flares. By combining emotional resilience with practical solutions, you can better navigate the ups and downs of rheumatoid arthritis.


Pregnancy and Rheumatoid Arthritis Flares

Pregnancy brings unique challenges for women with rheumatoid arthritis, as hormonal changes can affect disease activity and increase the risk of flares. It’s crucial to work closely with your healthcare provider to develop a treatment plan tailored to your needs during this time. Some medications commonly used to treat rheumatoid arthritis, such as methotrexate, may need to be stopped or adjusted, while others like prednisone may be considered safe under medical supervision.

Regular blood tests and careful monitoring throughout pregnancy help ensure both your health and your baby’s well-being. Lifestyle adjustments, including a nutritious diet and regular, gentle exercise, can further reduce the risk of flares and support a healthy pregnancy. Open communication with your healthcare team will help you navigate medication changes and manage symptoms, ensuring the best possible outcomes for you and your baby.

Case Study: Lasting Relief from RA Flare Ups

Patient: Jane, 54, accountant
Condition: Rheumatoid arthritis with frequent flare ups, unresponsive to NSAIDs alone
Treatment: 3 sessions of prolotherapy at ProHealth Clinic
Outcome: Jane reported a 70% reduction in flare frequency and severity, with improved joint function and energy at her 6-month follow-up. Jane noticed initial improvements within a few weeks of starting treatment, and credits positive thinking as part of her recovery process.

Are Treatments for RA Flare Ups Safe?

Most non-surgical treatments, including prolotherapy and DMARDs, are considered safe when performed by experienced clinicians. Clinical studies have demonstrated the safety and efficacy of these treatments, with evidence supporting their use in managing rheumatoid arthritis flare ups. Side effects are rare but may include temporary pain, swelling, or infection. Always consult a qualified practitioner to discuss risks and benefits [4].

How to Prevent Rheumatoid Arthritis Flare Ups

  • Take medications as prescribed
  • Manage stress and get enough sleep
  • Maintain a healthy weight and balanced diet
  • Exercise regularly, but avoid overexertion
  • Protect your joints during daily activities
  • Monitor for early signs of a flare up and act quickly
  • Engage in patient education to better understand your condition and recognize early warning signs of a flare.

Following these strategies can help prevent flares and support long-term disease management.

Frequently Asked Questions

How do I know if I’m having a rheumatoid arthritis flare up?

You may notice increased joint pain, swelling, stiffness, fatigue, and difficulty with daily activities. Flares can also cause low-grade fever and sleep disturbances.

What is the fastest way to relieve a rheumatoid arthritis flare up?

Rest, ice, and anti-inflammatory medications can provide quick relief. For longer-term results, work with your doctor to adjust your treatment plan and consider therapies like prolotherapy.

Is prolotherapy safe for rheumatoid arthritis?

Yes, prolotherapy is considered safe when performed by trained professionals. Side effects are rare and usually mild.

When should I see a doctor during a flare up?

See a doctor if you have severe pain, swelling,

continue
fever, or if your symptoms do not improve with home care. Early intervention can prevent complications.

Can I exercise during a flare up?

Gentle range-of-motion exercises are usually safe, but avoid strenuous activity. Consult your healthcare provider for personalized advice.

Contact ProHealth Clinic Today for Your FREE 15-Minute Discovery Call

Don’t let rheumatoid arthritis control your life any longer. Join the thousands of patients who have found lasting relief through prolotherapy at ProHealth Clinic.

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Email: info@prohealthclinic.co.uk

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Author Bio

Having performed over 10,000 procedures, Mr Oliver Eaton is one of the UK’s leading practitioners in the field of treating rheumatoid arthritis, with patients travelling to see him from across the UK, Europe, and the Middle East.

With over 12 years of clinical experience, Oliver is dedicated to helping patients understand their symptoms associated with rheumatoid arthritis and providing effective treatment options to alleviate them.

He qualified in Prolozone Therapy and Prolotherapy in America with the American Academy of Ozonotherapy. He continued on to complete further qualifications at the Royal Society of Medicine, Charing Cross Hospital in London, Keele University’s Anatomy & Surgical Training Centre, and the medical department of Heidelberg University in Germany.

Over the years he has had the privilege of treating many elite-level athletes, including both Olympic and Commonwealth medallists.

Mr Eaton’s expertise has been featured in many national news and media publications, including The TelegraphThe Daily MailThe Daily Express, Women’s Health Magazine, and The Scotsman.

Mr Eaton’s expertise has been featured in many national news and media publications, including The TelegraphThe Daily MailThe Daily Express, Women’s Health Magazine, and The Scotsman.

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References

  1. Smolen JS, et al. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-2038. Link
  2. Matcham F, et al. The impact of stress on the disease activity of rheumatoid arthritis. Rheumatology. 2014;53(2):331-342. Link
  3. van der Heijde D, et al. EULAR definition of erosive disease in rheumatoid arthritis. Ann Rheum Dis. 2013;72(4):479-481. Link
  4. Rabago D, et al. Prolotherapy in primary care practice. Prim Care. 2010;37(1):65-80. Link

Disclaimer: This article is for informational purposes only and does not substitute for professional medical advice. Always consult your healthcare provider before making treatment decisions.

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